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| 카탈로그 번호 | HD015012 |
|---|---|
| 설명 |
Recombinant Human CYP2B6 Protein, N-His (HD015012) expressed in E. coli, spanning Gly41-Arg491. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P20813 |
| 단백질 길이 | Gly41-Arg491 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 54.11 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | 1,4-cineole 2-exo-monooxygenase, CYP2B6, CYPIIB6, Cytochrome P450 2B6, Cytochrome P450 IIB1, EC:1.14.13.- |
| 배경 | Cytochrome P450 2B6 is a ~56 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2. Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs. 1. Lee, AJ. et al. (2003) Endocrinology 144, 3382-98. PMID: 12865317 2. Sridar, C. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 782-8. PMID: 21289075 3. Miyazawa, M. et al. (2001) Xenobiotica; the fate of foreign compounds in biological systems 31, 713-23. PMID: 11695850 4. Shah, MB. et al. (2012) Biochemistry 51, 7225-38. PMID: 22909231 |
| 참고사항 | For research use only |
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