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| 카탈로그 번호 | HD135012 |
|---|---|
| 설명 |
Recombinant Human DNAJC10 Protein, N-His (HD135012) expressed in E. coli, spanning Ser354-Asn555. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q8IXB1 |
| 단백질 길이 | Ser354-Asn555 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 25.47 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | DNAJC10, DnaJ homolog subfamily C member 10, EC:1.8.4.-, ER-resident protein ERdj5, ERDJ5, ERdj5, Endoplasmic reticulum DNA J domain-containing protein 5, MTHr, Macrothioredoxin |
| 배경 | Endoplasmic reticulum disulfide reductase DNAJC10 is a ~91 kDa protein. Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins. Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process. In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. 1. Cunnea, PM. et al. (2003) The Journal of biological chemistry 278, 1059-66. PMID: 12411443 2. Oka, OB. et al. (2013) Molecular cell 50, 793-804. PMID: 23769672 3. Cai, X. et al. (2023) The Journal of biological chemistry 299, 105274. PMID: 37739037 4. Dong, M. et al. (2008) Molecular biology of the cell 19, 2620-30. PMID: 18400946 5. Thomas, CG. et al. (2009) The Journal of biological chemistry 284, 6282-90. PMID: 19122239 |
| 참고사항 | For research use only |
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