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| 카탈로그 번호 | HD751012 |
|---|---|
| 설명 |
Recombinant Human GABRG2 Protein, N-His (HD751012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P18507 |
| 단백질 길이 | Thr90-Arg271 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | GABA(A) receptor subunit gamma-2, GABAAR subunit gamma-2, GABRG2, Gamma-aminobutyric acid receptor subunit gamma-2 |
| 배경 | Gamma-aminobutyric acid receptor subunit gamma-2 is a ~55 kDa protein. Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. 1. Caraiscos, VB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 3662-7. PMID: 14993607 2. Ranna, M. et al. (2006) BMC pharmacology 6, 1. PMID: 16412217 3. Fuchs, C. et al. (2013) The European journal of neuroscience 38, 3146-58. PMID: 23909897 4. Pritchett, DB. et al. (1989) Nature 338, 582-5. PMID: 2538761 5. Brown, LE. et al. (2014) Journal of visualized experiments : JoVE, e52115. PMID: 25489750 6. Shen, D. et al. (2017) Brain : a journal of neurology 140, 49-67. PMID: 27864268 7. Zhu, S. et al. (2018) Nature 559, 67-72. PMID: 29950725 8. Laverty, D. et al. (2019) Nature 565, 516-520. PMID: 30602789 |
| 참고사항 | For research use only |
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