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| 카탈로그 번호 | HD909012 |
|---|---|
| 설명 |
Recombinant Human GFI1 Protein, N-His (HD909012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q99684 |
| 단백질 길이 | Lys256-Lys422 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | GFI1, Growth factor independent protein 1, ZNF163, Zinc finger protein 163, Zinc finger protein Gfi-1 |
| 배경 | Zinc finger protein Gfi-1 is a ~45 kDa protein. Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. 1. Rödel, B. et al. (2000) The EMBO journal 19, 5845-55. PMID: 11060035 2. Dahl, R. et al. (2007) The Journal of biological chemistry 282, 6473-83. PMID: 17197705 3. Marteijn, JA. et al. (2007) Blood 110, 3128-35. PMID: 17646546 4. Montoya-Durango, DE. et al. (2008) The Journal of biological chemistry 283, 32056-65. PMID: 18805794 5. Basu, S. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 1433-8. PMID: 19164764 6. Liu, Q. et al. (2010) Oncogene 29, 2843-52. PMID: 20190815 7. Zweidler-Mckay, PA. et al. (1996) Molecular and cellular biology 16, 4024-34. PMID: 8754800 10. Sharif-Askari, E. et al. (2010) Molecular and cellular biology 30, 3929-42. PMID: 20547752 |
| 참고사항 | For research use only |
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