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| 카탈로그 번호 | HC924012 |
|---|---|
| 설명 |
Recombinant Human GNA15 Protein, N-His (HC924012) expressed in E. coli, spanning Glu42-Leu374. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P30679 |
| 단백질 길이 | Glu42-Leu374 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 40.96 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Epididymis tissue protein Li 17E, G alpha-15, G alpha-16, G-protein subunit alpha-15, G-protein subunit alpha-16, GNA15, GNA16, Guanine nucleotide-binding protein subunit alpha-15, Guanine nucleotide-binding protein subunit alpha-16 |
| 배경 | Guanine nucleotide-binding protein subunit alpha-15 is a ~43 kDa protein. Member of the G-protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses. 1. Marty, C. et al. (2003) Molecular and cellular biology 23, 3847-58. PMID: 12748287 2. Liu, AM. et al. (2010) Cellular signalling 22, 1448-58. PMID: 20639119 3. I, KY. et al. (2017) Frontiers in immunology 8, 373. PMID: 28421075 |
| 참고사항 | For research use only |
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