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| 카탈로그 번호 | HA105012 |
|---|---|
| 설명 |
Recombinant Human Histone H1.2 Protein, N-GST & C-His (HA105012) expressed in E. coli, spanning Ser41-Asn108. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P16403 |
| 단백질 길이 | Ser41-Asn108 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 35.12 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | H1-2, H1F2, HIST1H1C, Histone H1.2, Histone H1c, Histone H1d, Histone H1s-1 |
| 배경 | Histone H1.2 is a ~21 kDa protein. Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibers. Compared to other histone H1 variants, H1-2 plays an essnetial role in nucleosome condensation: its absence leads to global chromatin decompaction, which is not observed when depleting other histone H1 variants. Histone H1-2 also acts as a histone reader: specifically recognizes and binds histone H3 trimethylated at 'lys-27' (H3K27me3). Histones H1 also promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, possibly by facilitating restoration of H3K27me3 post-replication. 1. Kim, JM. et al. (2015) Scientific reports 5, 16714. PMID: 26581166 2. Salinas-Pena, M. et al. (2024) eLife 12. PMID: 38530350 3. Liu, C. et al. (2023) Nature communications 14, 4081. PMID: 37429872 4. Matthews, RE. et al. (2025) Molecular cell 85, 2503-2516.e8. PMID: 40516528 5. Pascal, C. et al. (2023) Molecular cell 83, 3801-3817.e8. PMID: 37922872 |
| 참고사항 | For research use only |
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