Human INPPL1 Recombinant Protein (N-His) (HD553012)

Name: Human INPPL1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD553012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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개요

카탈로그 번호	HD553012
설명	Recombinant Human INPPL1 Protein, N-His (HD553012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
발현 시스템	E. coli
등록번호	O15357
단백질 길이	Asp422-Thr730
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	EC:3.1.3.86, INPPL-1, INPPL1, Inositol polyphosphate phosphatase-like protein 1, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2, SH2 domain-containing inositol phosphatase 2, SHIP-2, SHIP2
배경	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 is a ~138 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. 1. Vandeput, F. et al. (2006) Cellular signalling 18, 2193-9. PMID: 16824732 2. Habib, T. et al. (1998) The Journal of biological chemistry 273, 18605-9. PMID: 9660833 3. Dyson, JM. et al. (2001) The Journal of cell biology 155, 1065-79. PMID: 11739414 4. Dyson, JM. et al. (2003) Blood 102, 940-8. PMID: 12676785 5. Prasad, NK. et al. (2005) The Journal of biological chemistry 280, 13129-36. PMID: 15668240 6. Hasegawa, J. et al. (2011) The Journal of cell biology 193, 901-16. PMID: 21624956 7. Prasad, N. et al. (2002) Journal of cell science 115, 3807-15. PMID: 12235291 8. Koch, A. et al. (2005) Oncogene 24, 3436-47. PMID: 15735664 9. Zhuang, G. et al. (2007) The Journal of biological chemistry 282, 2683-94. PMID: 17135240 10. Pengal, RA. et al. (2003) The Journal of biological chemistry 278, 22657-63. PMID: 12690104
참고사항	For research use only

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Human INPPL1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Human INPPL1 Recombinant Protein (N-His) (HD553012)

개요

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