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| 카탈로그 번호 | HA390022 |
|---|---|
| 설명 |
Recombinant Human KAT2B Protein, N-His (HA390022) expressed in E. coli, spanning Asn651-Lys818. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q92831 |
| 단백질 길이 | Asn651-Lys818 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 22.16 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EC:2.3.1.48, EC:2.3.1.57, Histone acetylase PCAF, Histone acetyltransferase KAT2B, Histone acetyltransferase PCAF, KAT2B, Lysine acetyltransferase 2B, P/CAF, P300/CBP-associated factor, PCAF, Spermidine acetyltransferase KAT2B |
| 배경 | Histone acetyltransferase KAT2B is a ~93 kDa protein. Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. 1. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521 2. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905 3. Martínez-Balbás, MA. et al. (2000) The EMBO journal 19, 662-71. PMID: 10675335 4. Xia, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 16564-9. PMID: 23001180 5. Lin, R. et al. (2013) Molecular cell 51, 506-518. PMID: 23932781 6. Chen, S. et al. (2016) Nature communications 7, 10734. PMID: 26867678 7. Fournier, M. et al. (2016) Nature communications 7, 13227. PMID: 27796307 8. Ghosh, TK. et al. (2018) Journal of molecular and cellular cardiology 114, 185-198. PMID: 29174768 9. Zhang, W. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 9855-60. PMID: 9707565 |
| 참고사항 | For research use only |
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