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| 카탈로그 번호 | HD421012 |
|---|---|
| 설명 |
Recombinant Human KCNK10 Protein, N-His (HD421012) expressed in E. coli, spanning Ser393-Asp497. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P57789 |
| 단백질 길이 | Ser393-Asp497 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 14.37 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | KCNK10, Outward rectifying potassium channel protein TREK-2, Potassium channel subfamily K member 10, TREK-2 K(+) channel subunit, TREK2 |
| 배경 | Potassium channel subfamily K member 10 is a ~59 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency. 1. Lesage, F. et al. (2000) The Journal of biological chemistry 275, 28398-405. PMID: 10880510 2. Dong, YY. et al. (2015) Science (New York, N.Y.) 347, 1256-9. PMID: 25766236 3. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430 4. Sorum, B. et al. (2024) Nature communications 15, 3142. PMID: 38605031 5. Royal, P. et al. (2019) Neuron 101, 232-245.e6. PMID: 30573346 |
| 참고사항 | For research use only |
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