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| 카탈로그 번호 | HD363012 |
|---|---|
| 설명 |
Recombinant Human KDM7A Protein, N-His (HD363012) expressed in E. coli, spanning Gln116-Asn479. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q6ZMT4 |
| 단백질 길이 | Gln116-Asn479 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 44.46 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EC:1.14.11.65, JHDM1D, JmjC domain-containing histone demethylation protein 1D, KDM7, KDM7A, KIAA1718, Lysine-specific demethylase 7, Lysine-specific demethylase 7A, [histone H3]-dimethyl-L-lysine9 demethylase 7A |
| 배경 | Lysine-specific demethylase 7A is a ~106 kDa protein. Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. 1. Horton, JR. et al. (2010) Nature structural & molecular biology 17, 38-43. PMID: 20023638 2. Qi, HH. et al. (2010) Nature 466, 503-7. PMID: 20622853 |
| 참고사항 | For research use only |
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