Human LRP6 Recombinant Protein (N-His) (HF964022)

Name: Human LRP6 Recombinant Protein (N-His)
Brand: abinScience
SKU: HF964022
Price: 211 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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50ug
100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HF964022
설명	Recombinant Human LRP6 Protein, N-His (HF964022) expressed in E. coli, spanning Ala20-Gly326. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
발현 시스템	E. coli
등록번호	O75581
단백질 길이	Ala20-Gly326
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
예측 분자량	36.69 kDa
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	LRP-6, LRP6, Low-density lipoprotein receptor-related protein 6
배경	Low-density lipoprotein receptor-related protein 6 is a ~180 kDa protein. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in various processes including retinal angiogenesis and bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. 1. Mao, B. et al. (2001) Nature 411, 321-5. PMID: 11357136 2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771 3. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503 4. Zeng, X. et al. (2005) Nature 438, 873-7. PMID: 16341017 5. Swiatek, W. et al. (2006) The Journal of biological chemistry 281, 12233-41. PMID: 16513652 6. Mi, K. et al. (2007) Journal of neurochemistry 101, 517-29. PMID: 17326769 7. Wei, Q. et al. (2007) The Journal of biological chemistry 282, 15903-11. PMID: 17400545 8. Piao, S. et al. (2008) PloS one 3, e4046. PMID: 19107203 9. Wu, G. et al. (2009) PloS one 4, e4926. PMID: 19293931 10. Chen, M. et al. (2009) The Journal of biological chemistry 284, 35040-8. PMID: 19801552
참고사항	For research use only