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| 카탈로그 번호 | HV357022 |
|---|---|
| 설명 |
Recombinant Human MAVS Protein, N-His (HV357022) expressed in E. coli, spanning Pro2-Pro97. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q7Z434 |
| 단백질 길이 | Pro2-Pro97 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 13.48 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CARD adapter inducing interferon beta, Cardif, IPS-1, IPS1, Interferon beta promoter stimulator protein 1, KIAA1271, MAVS, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, VISA, Virus-induced-signaling adapter |
| 배경 | Mitochondrial antiviral-signaling protein is a ~56 kDa protein. Adapter required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. 1. Seth, RB. et al. (2005) Cell 122, 669-82. PMID: 16125763 2. Kawai, T. et al. (2005) Nature immunology 6, 981-8. PMID: 16127453 3. Xu, LG. et al. (2005) Molecular cell 19, 727-40. PMID: 16153868 4. Meylan, E. et al. (2005) Nature 437, 1167-72. PMID: 16177806 5. Chiu, YH. et al. (2009) Cell 138, 576-91. PMID: 19631370 6. Oshiumi, H. et al. (2010) European journal of immunology 40, 940-8. PMID: 20127681 7. Dixit, E. et al. (2010) Cell 141, 668-81. PMID: 20451243 8. Oshiumi, H. et al. (2010) PloS one 5, e14258. PMID: 21170385 9. Wang, Y. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5304-13. PMID: 23087404 10. Liu, B. et al. (2017) Nature immunology 18, 214-224. PMID: 27992402 |
| 참고사항 | For research use only |
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