Human MBL-2 Recombinant Protein (N-His) (HY274042)

Name: Human MBL-2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HY274042
Price: 211 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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50ug
100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HY274042
설명	Recombinant Human MBL2 Protein, N-His (HY274042) expressed in E. coli, spanning Gly131-Ile248. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
발현 시스템	E. coli
등록번호	P11226
단백질 길이	Gly131-Ile248
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
예측 분자량	15.25 kDa
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	COLEC1, Collectin-1, MBL, MBL2, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
배경	Mannose-binding protein C is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA. 1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269 2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085 3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089 4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411 5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758 6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429 7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295 8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342
참고사항	For research use only