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| 카탈로그 번호 | HD222012 |
|---|---|
| 설명 |
Recombinant Human MBTPS1 Protein, N-His (HD222012) expressed in E. coli, spanning Arg191-Pro615. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q14703 |
| 단백질 길이 | Arg191-Pro615 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 48.59 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EC:3.4.21.112, Endopeptidase S1P, KIAA0091, MBTPS1, Membrane-bound transcription factor site-1 protease, S1P, SKI-1, SKI1, Subtilisin/kexin-isozyme 1 |
| 배경 | Membrane-bound transcription factor site-1 protease is a ~117 kDa protein. Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates include SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6, ATF6B and FAM20C. Cleaves substrates after Arg-Ser-Val-Leu (SREBP2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Also mediates the first step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. 1. Touré, BB. et al. (2000) The Journal of biological chemistry 275, 2349-58. PMID: 10644685 2. Okada, T. et al. (2003) The Journal of biological chemistry 278, 31024-32. PMID: 12782636 3. Marschner, K. et al. (2011) Science (New York, N.Y.) 333, 87-90. PMID: 21719679 4. Chen, X. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34349020 7. Murakami, T. et al. (2006) Journal of neurochemistry 96, 1090-100. PMID: 16417584 |
| 참고사항 | For research use only |
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