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| 카탈로그 번호 | HA348012 |
|---|---|
| 설명 |
Recombinant Human MCOLN1 Protein, N-His (HA348012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q9GZU1 |
| 단백질 길이 | Asn87-Arg298 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | MCOLN1, MG-2, ML1, ML4, Mucolipidin, Mucolipin-1, TRPML1, Transient receptor potential channel mucolipin 1 |
| 배경 | Mucolipin-1 is a ~65 kDa protein. Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. 1. Bassi, MT. et al. (2000) American journal of human genetics 67, 1110-20. PMID: 11013137 2. LaPlante, JM. et al. (2002) FEBS letters 532, 183-7. PMID: 12459486 3. Raychowdhury, MK. et al. (2004) Human molecular genetics 13, 617-27. PMID: 14749347 4. LaPlante, JM. et al. (2004) Biochemical and biophysical research communications 322, 1384-91. PMID: 15336987 5. Dong, XP. et al. (2008) Nature 455, 992-6. PMID: 18794901 6. Medina, DL. et al. (2015) Nature cell biology 17, 288-99. PMID: 25720963 7. Krishna, S. et al. (2016) Developmental cell 38, 536-47. PMID: 27623384 8. Schmiege, P. et al. (2017) Nature 550, 366-370. PMID: 29019983 |
| 참고사항 | For research use only |
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