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| 카탈로그 번호 | HA053012 |
|---|---|
| 설명 |
Recombinant Human MCOLN3 Protein, N-His (HA053012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q8TDD5 |
| 단백질 길이 | Asn84-His283 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 25.56 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | MCOLN3, Mucolipin-3, TRPML3, Transient receptor potential channel mucolipin 3 |
| 배경 | Mucolipin-3 is a ~64 kDa protein. Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Also permeable to Mg(2+), Na(+) and K(+). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. 1. Kim, HJ. et al. (2008) The EMBO journal 27, 1197-205. PMID: 18369318 2. Martina, JA. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1143-56. PMID: 19497048 3. Kim, HJ. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1157-67. PMID: 19522758 4. Curcio-Morelli, C. et al. (2010) Journal of cellular physiology 222, 328-35. PMID: 19885840 5. Zhou, X. et al. (2017) Nature structural & molecular biology 24, 1146-1154. PMID: 29106414 6. Lelouvier, B. et al. (2011) The Journal of biological chemistry 286, 9826-32. PMID: 21245134 7. Guo, Z. et al. (2013) PloS one 8, e58174. PMID: 23469151 |
| 참고사항 | For research use only |
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