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| 카탈로그 번호 | HD957012 |
|---|---|
| 설명 |
Recombinant Human MICAL2 Protein, N-His (HD957012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | O94851 |
| 단백질 길이 | Met1-His486 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EC:1.14.13.225, KIAA0750, MICAL C-terminal-like protein, MICAL-2, MICAL2, MICAL2PV1, MICAL2PV2, MICALCL, Mical-cL, Molecule interacting with CasL protein 2, [F-actin]-monooxygenase MICAL2 |
| 배경 | [F-actin]-monooxygenase MICAL2 is a ~219 kDa protein. Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. 1. Lundquist, MR. et al. (2014) Cell 156, 563-76. PMID: 24440334 2. Wu, H. et al. (2018) Scientific reports 8, 937. PMID: 29343822 3. Galloni, C. et al. (2021) The Journal of cell biology 220. PMID: 34106209 |
| 참고사항 | For research use only |
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