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| 카탈로그 번호 | HC166012 |
|---|---|
| 설명 |
Recombinant Human NBR1 Protein, N-His (HC166012) expressed in E. coli, spanning Ser372-Asp479. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q14596 |
| 단백질 길이 | Ser372-Asp479 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 14.36 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | 1A13B, Cell migration-inducing gene 19 protein, KIAA0049, M17S2, Membrane component chromosome 17 surface marker 2, NBR1, Neighbor of BRCA1 gene 1 protein, Next to BRCA1 gene 1 protein, Protein 1A1-3B |
| 배경 | Next to BRCA1 gene 1 protein is a ~107 kDa protein. Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway. 1. Walinda, E. et al. (2014) The Journal of biological chemistry 289, 13890-902. PMID: 24692539 2. Zeng, Y. et al. (2021) PLoS pathogens 17, e1009300. PMID: 33577621 3. Nicot, AS. et al. (2014) Autophagy 10, 1036-53. PMID: 24879152 4. Turco, E. et al. (2021) Nature communications 12, 5212. PMID: 34471133 5. Song, H. et al. (2024) International journal of biological sciences 20, 701-717. PMID: 38169523 6. Cai, Y. et al. (2022) Biochemical and biophysical research communications 623, 140-147. PMID: 35914352 |
| 참고사항 | For research use only |
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