中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HD945012 |
|---|---|
| 설명 |
Recombinant Human NR4A1 Protein, N-His (HD945012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P22736 |
| 단백질 길이 | Lys397-Phe598 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Early response protein NAK1, GFRP1, HMR, NAK1, NR4A1, Nuclear hormone receptor NUR/77, Nuclear receptor subfamily 4immunitygroup A member 1, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3 |
| 배경 | Nuclear receptor subfamily 4immunitygroup A member 1 is a ~64 kDa protein. Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA). 1. Zhan, Y. et al. (2008) Nature chemical biology 4, 548-56. PMID: 18690216 2. Woronicz, JD. et al. (1994) Nature 367, 277-81. PMID: 8121493 3. Philips, A. et al. (1997) Molecular and cellular biology 17, 5946-51. PMID: 9315652 4. Zhan, YY. et al. (2012) Nature chemical biology 8, 897-904. PMID: 22983157 5. Harant, H. et al. (2004) Nucleic acids research 32, 5280-90. PMID: 15466594 |
| 참고사항 | For research use only |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
