Human PADI4 Recombinant Protein (N-Strep) (HV433032)

Name: Human PADI4 Recombinant Protein (N-Strep)
Brand: abinScience
SKU: HV433032
Price: 211 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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50ug
100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HV433032
설명	Recombinant Human PADI4 Protein, N-Strep (HV433032) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
발현 시스템	E. coli
등록번호	Q9UM07
단백질 길이	Met1-Pro663
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
예측 분자량	75.31 kDa
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	EC:3.5.3.15, HL-60 PAD, PAD4, PADI4, PADI5, PDI5, Peptidylarginine deiminase IV, Protein-arginine deiminase type IV, Protein-arginine deiminase type-4
배경	Protein-arginine deiminase type-4 is a ~74 kDa protein. Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. 1. Cuthbert, GL. et al. (2004) Cell 118, 545-53. PMID: 15339660 2. Wang, Y. et al. (2004) Science (New York, N.Y.) 306, 279-83. PMID: 15345777 3. Arita, K. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 5291-6. PMID: 16567635 4. Horikoshi, N. et al. (2011) Acta crystallographica. Section D, Biological crystallography 67, 112-8. PMID: 21245532 6. Lee, YH. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 3611-6. PMID: 15731352
참고사항	For research use only