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| 카탈로그 번호 | HD352012 |
|---|---|
| 설명 |
Recombinant Human PAQR3 Protein, N-His-KSI (HD352012) expressed in E. coli, spanning His2-Trp74. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q6TCH7 |
| 단백질 길이 | His2-Trp74 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 24.37 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | PAQR3, Progestin and adipoQ receptor family member 3, Progestin and adipoQ receptor family member III, RKTG, Raf kinase trapping to Golgi |
| 배경 | Progestin and adipoQ receptor family member 3 is a ~36 kDa protein. Golgi-scaffold protein which modulates its interactors acitivies by anchoring them to the Golgi apparatus. Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus. Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis. Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation. 1. Luo, X. et al. (2008) The Biochemical journal 414, 399-406. PMID: 18547165 2. Xu, D. et al. (2015) Nature communications 6, 8100. PMID: 26311497 |
| 참고사항 | For research use only |
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