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| 카탈로그 번호 | HD908012 |
|---|---|
| 설명 |
Recombinant Human PARP9 Protein, N-His (HD908012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q8IXQ6 |
| 단백질 길이 | Asn310-Asn493 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ADP-ribosyltransferase diphtheria toxin-like 9, ARTD9, B aggressive lymphoma protein, BAL, BAL1, EC:2.4.2.-, PARP-9, PARP9, Poly [ADP-ribose] polymerase 9, Protein mono-ADP-ribosyltransferase PARP9 |
| 배경 | Protein mono-ADP-ribosyltransferase PARP9 is a ~96 kDa protein. ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones. During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1. Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. 1. Juszczynski, P. et al. (2006) Molecular and cellular biology 26, 5348-59. PMID: 16809771 2. Yan, Q. et al. (2013) Molecular and cellular biology 33, 845-57. PMID: 23230272 3. Zhang, Y. et al. (2015) Nature immunology 16, 1215-27. PMID: 26479788 4. Iwata, H. et al. (2016) Nature communications 7, 12849. PMID: 27796300 5. Yang, CS. et al. (2017) Molecular cell 66, 503-516.e5. PMID: 28525742 |
| 참고사항 | For research use only |
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