

| 카탈로그 번호 | HC792012 |
|---|---|
| 설명 |
Recombinant Human PLXNB2 Protein, N-His (HC792012) expressed in E. coli, spanning Gln56-Gly225. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | O15031 |
| 단백질 길이 | Gln56-Gly225 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 20.74 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | KIAA0315, MM1, PLXNB2, Plexin-B2 |
| 배경 | Plexin-B2 is a ~205 kDa protein. Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. 1. Yu, W. et al. (2017) Cell 171, 849-864.e25. PMID: 29100074 2. Bai, R. et al. (2020) The EMBO journal 39, e103325. PMID: 32510170 3. Perrot, V. et al. (2002) The Journal of biological chemistry 277, 43115-20. PMID: 12183458 4. Conrotto, P. et al. (2004) Oncogene 23, 5131-7. PMID: 15184888 |
| 참고사항 | For research use only |
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