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| 카탈로그 번호 | HD563012 |
|---|---|
| 설명 |
Recombinant Human RPE65 Protein, N-His (HD563012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q16518 |
| 단백질 길이 | Met1-Ser533 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | All-trans-retinyl-palmitate hydrolase, EC:3.1.1.64, EC:5.3.3.22, Lutein isomerase, Meso-zeaxanthin isomerase, RPE65, Retinal pigment epithelium-specific 65 kDa protein, Retinoid isomerohydrolase, Retinol isomerase |
| 배경 | Retinoid isomerohydrolase is a ~60 kDa protein. Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. 1. Moiseyev, G. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 12413-8. PMID: 16116091 2. Jacobson, SG. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 15123-8. PMID: 17848510 3. Shyam, R. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 10882-10887. PMID: 28874556 |
| 참고사항 | For research use only |
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