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| 카탈로그 번호 | HD982012 |
|---|---|
| 설명 |
Recombinant Human SAR1A Protein, N-His (HD982012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q9NR31 |
| 단백질 길이 | Met1-Asp198 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | COPII-associated small GTPase, EC:3.6.5.2, SAR1, SAR1A, SARA, SARA1, Secretion-associated Ras-related GTPase 1A, Small COPII coat GTPase SAR1A |
| 배경 | Small COPII coat GTPase SAR1A is a ~22 kDa protein. Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi. The GTPase activity of SAR1 by controlling the timing of COPII budding regulates the size of the formed vesicles and is important for cargo selection depending on their size. Together with SEC16A, forms the organized scaffold defining endoplasmic reticulum exit sites (ERES), some specific domains of the endoplasmic reticulum where COPII vesicles form. 1. Cutrona, MB. et al. (2013) Traffic (Copenhagen, Denmark) 14, 691-708. PMID: 23433038 2. Melville, DB. et al. (2020) The Journal of biological chemistry 295, 8401-8412. PMID: 32358066 3. Huang, Q. et al. (2023) Proteins 91, 518-531. PMID: 36369712 4. Watson, P. et al. (2006) Traffic (Copenhagen, Denmark) 7, 1678-87. PMID: 17005010 5. Chen, J. et al. (2021) Nature 596, 281-284. PMID: 34290409 |
| 참고사항 | For research use only |
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