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| 카탈로그 번호 | HD851012 |
|---|---|
| 설명 |
Recombinant Human SCN1B Protein, N-His (HD851012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q07699 |
| 단백질 길이 | Gly19-Lys149 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | SCN1B, Sodium channel regulatory subunit beta-1 |
| 배경 | Sodium channel regulatory subunit beta-1 is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. 1. Qin, N. et al. (2003) European journal of biochemistry 270, 4762-70. PMID: 14622265 2. Spampanato, J. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 10022-34. PMID: 15525788 3. Watanabe, H. et al. (2008) The Journal of clinical investigation 118, 2260-8. PMID: 18464934 4. Patino, GA. et al. (2009) The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 10764-78. PMID: 19710327 5. Baroni, D. et al. (2018) Human mutation 39, 1402-1415. PMID: 29992740 6. Fan, X. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2220578120. PMID: 36696443 7. Makita, N. et al. (1994) The Journal of biological chemistry 269, 7571-8. PMID: 8125980 8. McClatchey, AI. et al. (1993) Human molecular genetics 2, 745-9. PMID: 8394762 9. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606 |
| 참고사항 | For research use only |
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