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| 카탈로그 번호 | HD113012 |
|---|---|
| 설명 |
Recombinant Human SEC61A1 Protein, N-GST & C-His (HD113012) expressed in E. coli, spanning Ser376-Ala420. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P61619 |
| 단백질 길이 | Ser376-Ala420 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 33.34 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Protein transport protein Sec61 subunit alpha isoform 1, SEC61A, SEC61A1, Sec61 alpha-1 |
| 배경 | Protein transport protein Sec61 subunit alpha isoform 1 is a ~52 kDa protein. Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. 1. Meacock, SL. et al. (2002) Molecular biology of the cell 13, 4114-29. PMID: 12475939 2. Lang, S. et al. (2012) Journal of cell science 125, 1958-69. PMID: 22375059 3. Schubert, D. et al. (2018) The Journal of allergy and clinical immunology 141, 1427-1438. PMID: 28782633 4. Haßdenteufel, S. et al. (2018) Cell reports 23, 1373-1386. PMID: 29719251 5. Chitwood, PJ. et al. (2020) Nature 584, 630-634. PMID: 32814900 6. McGilvray, PT. et al. (2020) eLife 9. PMID: 32820719 7. Sundaram, A. et al. (2022) Nature 611, 167-172. PMID: 36261522 8. Do, H. et al. (1996) Cell 85, 369-78. PMID: 8616892 |
| 참고사항 | For research use only |
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