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| 카탈로그 번호 | HW700012 |
|---|---|
| 설명 |
Recombinant Human SEPHS1 Protein, N-His (HW700012) expressed in E. coli, spanning Ser2-Ser392. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P49903 |
| 단백질 길이 | Ser2-Ser392 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 45.22 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EC:2.7.9.3, SELD, SEPHS1, SPS, SPS1, Selenide, water dikinase 1, Selenium donor protein 1, Selenophosphate synthase 1 |
| 배경 | Zincore component SEPHS1 is a ~42 kDa protein. Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression. The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif. Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability. Plays an essential role in redox homeostasis. May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP. 1. Bianchi, D. et al. (2025) Science (New York, N.Y.) 389, eadv2861. PMID: 40608935 2. Lee, MO. et al. (2019) Biochemical and biophysical research communications 520, 406-412. PMID: 31607477 3. Low, SC. et al. (1995) The Journal of biological chemistry 270, 21659-64. PMID: 7665581 4. Tamura, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 16162-7. PMID: 15534230 |
| 참고사항 | For research use only |
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