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| 카탈로그 번호 | HD946012 |
|---|---|
| 설명 |
Recombinant Human SESN1 Protein, N-His (HD946012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q9Y6P5 |
| 단백질 길이 | Glu54-Gly220 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EC:1.11.1.-, PA26, SESN1, SEST1, Sestrin-1, p53-regulated protein PA26 |
| 배경 | Sestrin-1 is a ~56 kDa protein. Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. 1. Chantranupong, L. et al. (2014) Cell reports 9, 1-8. PMID: 25263562 2. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 3. Bae, SH. et al. (2013) Cell metabolism 17, 73-84. PMID: 23274085 4. Budanov, AV. et al. (2004) Science (New York, N.Y.) 304, 596-600. PMID: 15105503 |
| 참고사항 | For research use only |
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