Human SESN2 Recombinant Protein (N-His) (HD911012)

Name: Human SESN2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD911012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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개요

카탈로그 번호	HD911012
설명	Recombinant Human SESN2 Protein, N-His (HD911012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
발현 시스템	E. coli
등록번호	P58004
단백질 길이	Gly66-Thr480
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	EC:1.11.1.-, Hi95, Hypoxia-induced gene, SESN2, SEST2, Sestrin-2
배경	Sestrin-2 is a ~54 kDa protein. Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1. 1. Budanov, AV. et al. (2008) Cell 134, 451-60. PMID: 18692468 2. Chantranupong, L. et al. (2014) Cell reports 9, 1-8. PMID: 25263562 3. Parmigiani, A. et al. (2014) Cell reports 9, 1281-91. PMID: 25457612 4. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 5. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190 6. Kim, H. et al. (2015) Nature communications 6, 10025. PMID: 26612684 7. Lear, TB. et al. (2019) The Journal of biological chemistry 294, 16527-16534. PMID: 31586034 8. Wang, D. et al. (2022) Molecular cell 82, 770-784.e9. PMID: 35114100 9. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 10. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027
참고사항	For research use only

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Human SESN2 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

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Working Solution

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Human SESN2 Recombinant Protein (N-His) (HD911012)

개요

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