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| 카탈로그 번호 | HC159012 |
|---|---|
| 설명 |
Recombinant Human SLC7A11 Protein, N-GST & C-His (HC159012) expressed in E. coli, spanning Met1-Arg42. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q9UPY5 |
| 단백질 길이 | Met1-Arg42 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 32.75 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, Cystine/glutamate transporter, SLC7A11, Solute carrier family 7 member 11, xCT |
| 배경 | Cystine/glutamate transporter is a ~55 kDa protein. Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress. The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. Acts as an inhibitor of ferroptosis by mediating the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Also inhibits ferroptosis by acting as an atypical proton transporter that mediates a slow proton efflux from lysosomes via cystine and glutamate flux. 1. Bridges, CC. et al. (2001) Investigative ophthalmology & visual science 42, 47-54. PMID: 11133847 2. Bassi, MT. et al. (2001) Pflugers Archiv : European journal of physiology 442, 286-96. PMID: 11417227 3. Jiménez-Vidal, M. et al. (2004) The Journal of biological chemistry 279, 11214-21. PMID: 14722095 4. Gasol, E. et al. (2004) The Journal of biological chemistry 279, 31228-36. PMID: 15151999 5. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232 6. Fiore, A. et al. (2022) Molecular cell 82, 920-932.e7. PMID: 35245456 7. Yan, R. et al. (2022) Cell research 32, 687-690. PMID: 35352032 8. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981 |
| 참고사항 | For research use only |
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