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| 카탈로그 번호 | HC815012 |
|---|---|
| 설명 |
Recombinant Human SLCO4C1 Protein, N-His (HC815012) expressed in E. coli, spanning Met472-Phe580. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q6ZQN7 |
| 단백질 길이 | Met472-Phe580 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 14.09 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | OATP-H, OATP-M1, OATP4C1, OATPX, Organic anion transporter M1, Organic anion transporting polypeptide 4C1, SLC21A20, SLCO4C1, Solute carrier family 21 member 20, Solute carrier organic anion transporter family member 4C1 |
| 배경 | Solute carrier organic anion transporter family member 4C1 is a ~78 kDa protein. Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney. Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate. Transport is independent of sodium, chloride ion, and ATP. Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter. The driving force for this transport activity is currently not known. 1. Mikkaichi, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 3569-74. PMID: 14993604 2. Leuthold, S. et al. (2009) American journal of physiology. Cell physiology 296, C570-82. PMID: 19129463 3. Yamaguchi, H. et al. (2010) Drug metabolism and pharmacokinetics 25, 314-7. PMID: 20610891 4. Taghikhani, E. et al. (2019) PloS one 14, e0213747. PMID: 30865704 5. Taghikhani, E. et al. (2020) Amino acids 52, 975-985. PMID: 32642843 |
| 참고사항 | For research use only |
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