中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HF766012 |
|---|---|
| 설명 |
Recombinant Human SRGAP2 Protein, N-His (HF766012) expressed in E. coli, spanning Thr494-Phe679. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | O75044 |
| 단백질 길이 | Thr494-Phe679 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 23.51 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ARHGAP34, FNBP2, Formin-binding protein 2, KIAA0456, Rho GTPase-activating protein 34, SLIT-ROBO Rho GTPase-activating protein 2, SRGAP2, SRGAP2A, srGAP2 |
| 배경 | SLIT-ROBO Rho GTPase-activating protein 2 is a ~120 kDa protein. Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation. Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions. 1. Guo, S. et al. (2010) The Journal of biological chemistry 285, 35133-41. PMID: 20810653 2. Fossati, M. et al. (2016) Neuron 91, 356-69. PMID: 27373832 3. Sporny, M. et al. (2017) Molecular biology and evolution 34, 1463-1478. PMID: 28333212 4. Charrier, C. et al. (2012) Cell 149, 923-35. PMID: 22559944 5. Mason, FM. et al. (2011) The Journal of biological chemistry 286, 6577-86. PMID: 21148482 |
| 참고사항 | For research use only |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
