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| 카탈로그 번호 | HD136012 |
|---|---|
| 설명 |
Recombinant Human TBC1D5 Protein, N-His (HD136012) expressed in E. coli, spanning Ser43-Ser266. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q92609 |
| 단백질 길이 | Ser43-Ser266 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 28.86 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | KIAA0210, TBC1 domain family member 5, TBC1D5 |
| 배경 | TBC1 domain family member 5 is a ~89 kDa protein. May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. 1. Seaman, MN. et al. (2009) Journal of cell science 122, 2371-82. PMID: 19531583 2. Harbour, ME. et al. (2010) Journal of cell science 123, 3703-17. PMID: 20923837 3. Popovic, D. et al. (2012) Molecular and cellular biology 32, 1733-44. PMID: 22354992 4. Popovic, D. et al. (2014) EMBO reports 15, 392-401. PMID: 24603492 |
| 참고사항 | For research use only |
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