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| 카탈로그 번호 | HD756012 |
|---|---|
| 설명 |
Recombinant Human TBXAS1 Protein, N-His (HD756012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P24557 |
| 단백질 길이 | Gly62-Arg533 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CYP5, CYP5A1, Cytochrome P450 5A1, EC:4.2.1.152, EC:5.3.99.5, Hydroperoxy icosatetraenoate dehydratase, TBXAS1, TXA synthase, TXAS, TXS, Thromboxane-A synthase |
| 배경 | Thromboxane-A synthase is a ~60 kDa protein. Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. 1. Hsu, PY. et al. (2000) Archives of biochemistry and biophysics 383, 119-27. PMID: 11097184 2. Wang, LH. et al. (2001) The Journal of biological chemistry 276, 14737-43. PMID: 11297515 3. Chen, CY. et al. (2012) Pharmacogenetics and genomics 22, 653-8. PMID: 22735388 4. Matsunobu, T. et al. (2013) Journal of lipid research 54, 2979-87. PMID: 24009185 5. Yokoyama, C. et al. (1993) FEBS letters 318, 91-4. PMID: 8436233 6. Hsu, PY. et al. (1999) The Journal of biological chemistry 274, 762-9. PMID: 9873013 7. Yeh, HC. et al. (2007) Archives of biochemistry and biophysics 461, 159-68. PMID: 17459323 |
| 참고사항 | For research use only |
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