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| 카탈로그 번호 | HV059022 |
|---|---|
| 설명 |
Recombinant Human TNPO1 Protein, N-His (HV059022) expressed in E. coli, spanning Cys613-Val898. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q92973 |
| 단백질 길이 | Cys613-Val898 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 34.64 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Importin beta-2, KPNB2, Karyopherin beta-2, M9 region interaction protein, MIP, MIP1, TNPO1, TRN, Transportin-1 |
| 배경 | Transportin-1 is a ~102 kDa protein. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 1. Barraud, P. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E1852-61. PMID: 24753571 2. Dean, KA. et al. (2001) Journal of cell science 114, 3479-85. PMID: 11682607 3. Fritz, J. et al. (2009) Molecular and cellular biology 29, 1487-97. PMID: 19124606 4. Yang, TJ. et al. (2022) The Journal of cell biology 221. PMID: 35446349 |
| 참고사항 | For research use only |
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