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| 카탈로그 번호 | HD030012 |
|---|---|
| 설명 |
Recombinant Human TXK Protein, N-His (HD030012) expressed in E. coli, spanning Ile85-Trp527. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P42681 |
| 단백질 길이 | Ile85-Trp527 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 53.87 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EC:2.7.10.2, PTK4, Protein-tyrosine kinase 4, RLK, Resting lymphocyte kinase, TXK, Tyrosine-protein kinase TXK |
| 배경 | Tyrosine-protein kinase TXK is a ~61 kDa protein. Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. 1. Takeba, Y. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 2365-70. PMID: 11859127 2. Maruyama, T. et al. (2007) Clinical and experimental immunology 147, 164-75. PMID: 17177976 |
| 참고사항 | For research use only |
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