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| 카탈로그 번호 | HC157012 |
|---|---|
| 설명 |
Recombinant Human TYROBP Protein, N-His (HC157012) expressed in E. coli, spanning Leu22-Lys113. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | O43914 |
| 단백질 길이 | Leu22-Lys113 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 12.34 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | DAP12, DNAX-activation protein 12, KAR-associated protein, KARAP, Killer-activating receptor-associated protein, TYRO protein tyrosine kinase-binding protein, TYROBP |
| 배경 | TYRO protein tyrosine kinase-binding protein is a ~12 kDa protein. Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation. Also has an inhibitory role in some cells. Non-covalently associates with activating receptors of the CD300 family to mediate cell activation. Also mediates cell activation through association with activating receptors of the CD200R family. 1. Dietrich, J. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 9-12. PMID: 10604985 2. Lanier, LL. et al. (1998) Nature 391, 703-7. PMID: 9490415 3. Lanier, LL. et al. (1998) Immunity 8, 693-701. PMID: 9655483 4. Nakano-Yokomizo, T. et al. (2011) The Journal of experimental medicine 208, 1661-71. PMID: 21727189 5. Aguilar, H. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 6703-11. PMID: 15557162 6. Martínez-Barriocanal, A. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 177, 2819-30. PMID: 16920917 7. Yamanishi, Y. et al. (2008) Blood 111, 688-98. PMID: 17928527 8. Niizuma, K. et al. (2015) The Journal of biological chemistry 290, 22298-308. PMID: 26221034 9. Bakker, AB. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 9792-6. PMID: 10449773 |
| 참고사항 | For research use only |
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