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| 카탈로그 번호 | HD948012 |
|---|---|
| 설명 |
Recombinant Human USP49 Protein, N-His (HD948012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q70CQ1 |
| 단백질 길이 | Ser356-Ser688 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Deubiquitinating enzyme 49, EC:3.4.19.12, USP49, Ubiquitin carboxyl-terminal hydrolase 49, Ubiquitin thioesterase 49, Ubiquitin-specific-processing protease 49 |
| 배경 | Ubiquitin carboxyl-terminal hydrolase 49 is a ~79 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity. Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1. Also regulates the mitotic spindle checkpoint and prevents aneuploidy. 1. Zhang, Z. et al. (2013) Genes & development 27, 1581-95. PMID: 23824326 2. Matsui, M. et al. (2022) Gene 833, 146599. PMID: 35598681 3. Luo, K. et al. (2017) The EMBO journal 36, 1434-1446. PMID: 28363942 4. Campos-Iglesias, D. et al. (2023) Cell death & disease 14, 60. PMID: 36702832 5. Ye, L. et al. (2019) PLoS pathogens 15, e1007680. PMID: 30943264 6. Pan, T. et al. (2019) eLife 8. PMID: 31397674 |
| 참고사항 | For research use only |
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