中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HD003012 |
|---|---|
| 설명 |
Recombinant Human USP51 Protein, N-His (HD003012) expressed in E. coli, spanning Asn370-Asp711. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q70EK9 |
| 단백질 길이 | Asn370-Asp711 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 41.09 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Deubiquitinating enzyme 51, EC:3.4.19.12, USP51, Ubiquitin carboxyl-terminal hydrolase 51, Ubiquitin thioesterase 51, Ubiquitin-specific-processing protease 51 |
| 배경 | Ubiquitin carboxyl-terminal hydrolase 51 is a ~79 kDa protein. Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1. 1. Wang, Z. et al. (2016) Genes & development 30, 946-59. PMID: 27083998 2. Walser, F. et al. (2020) Molecular cell 80, 423-436.e9. PMID: 33022275 3. Hang, Q. et al. (2021) Nature communications 12, 4033. PMID: 34188037 4. Zhou, Z. et al. (2017) American journal of cancer research 7, 2020-2031. PMID: 29119051 |
| 참고사항 | For research use only |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
