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| 카탈로그 번호 | HC782012 |
|---|---|
| 설명 |
Recombinant Human WDR59 Protein, N-His (HC782012) expressed in E. coli, spanning Ala2-Arg315. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q6PJI9 |
| 단백질 길이 | Ala2-Arg315 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 38.62 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | GATOR2 complex protein WDR59, KIAA1923, WD repeat-containing protein 59, WDR59 |
| 배경 | GATOR2 complex protein WDR59 is a ~109 kDa protein. As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. 1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238 2. Parmigiani, A. et al. (2014) Cell reports 9, 1281-91. PMID: 25457612 3. Saxton, RA. et al. (2016) Nature 536, 229-33. PMID: 27487210 4. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 5. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027 6. Zhang, Y. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2212330120. PMID: 36577058 |
| 참고사항 | For research use only |
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