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| 카탈로그 번호 | HC167012 |
|---|---|
| 설명 |
Recombinant Human XBP1 Protein, N-His-SUMO & C-Strep (HC167012) expressed in E. coli, spanning Ser68-Lys151. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P17861 |
| 단백질 길이 | Ser68-Lys151 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 23.40 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | TREB-5, TREB5, Tax-responsive element-binding protein 5, X-box-binding protein 1, X-box-binding protein 1, cytoplasmic form, X-box-binding protein 1, luminal form, XBP-1, XBP1, XBP2 |
| 배경 | X-box-binding protein 1 is a ~28 kDa protein. Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. 1. Reimold, AM. et al. (2001) Nature 412, 300-7. PMID: 11460154 2. Winnay, JN. et al. (2010) Nature medicine 16, 438-45. PMID: 20348923 3. Ponath, PD. et al. (1993) The Journal of biological chemistry 268, 17074-82. PMID: 8349596 |
| 참고사항 | For research use only |
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