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| 카탈로그 번호 | HX078022 |
|---|---|
| 설명 |
Recombinant Human YBX1 Protein, N-His-KSI (HX078022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P67809 |
| 단백질 길이 | Thr57-Thr126 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CBF-A, CCAAT-binding transcription factor I subunit A, DBPB, DNA-binding protein B, EFI-A, Enhancer factor I subunit A, NSEP1, Nuclease-sensitive element-binding protein 1, Y-box transcription factor, Y-box-binding protein 1, YB-1, YB1, YBX1 |
| 배경 | Y-box-binding protein 1 is a ~35 kDa protein. DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay. Component of the CRD-mediated complex that promotes MYC mRNA stability. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. 1. Chen, CY. et al. (2000) Genes & development 14, 1236-48. PMID: 10817758 2. Capowski, EE. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 5970-6. PMID: 11698476 3. Gaudreault, I. et al. (2004) Nucleic acids research 32, 316-27. PMID: 14718551 4. Chattopadhyay, R. et al. (2008) Molecular and cellular biology 28, 7066-80. PMID: 18809583 5. Chen, X. et al. (2019) Nature cell biology 21, 978-990. PMID: 31358969 6. Horwitz, EM. et al. (1994) The Journal of biological chemistry 269, 14130-9. PMID: 8188694 7. Ray, D. et al. (2009) Nature biotechnology 27, 667-70. PMID: 19561594 8. Weidensdorfer, D. et al. (2009) RNA (New York, N.Y.) 15, 104-15. PMID: 19029303 |
| 참고사항 | For research use only |
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