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| 카탈로그 번호 | MV480011 |
|---|---|
| 설명 |
Recombinant Mouse CD270/TNFRSF14 Protein, C-Fc (MV480011) expressed in Mammalian Cells, spanning Met1-Gln206. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | Mammalian cells |
| 등록번호 | Q80WM9 |
| 단백질 길이 | Met1-Gln206 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Mus musculus (Mouse) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 48.94 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CD270, HVEA, HVEM, Herpes virus entry mediator A, Herpesvirus entry mediator A, HveA, TNFRSF14, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2 |
| 배경 | Tumor necrosis factor receptor superfamily member 14 is a ~30 kDa protein. Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. 1. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044 2. Tu, TC. et al. (2015) The Journal of experimental medicine 212, 415-29. PMID: 25711213 3. Shui, JW. et al. (2012) Nature 488, 222-5. PMID: 22801499 4. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026 |
| 참고사항 | For research use only |
Immobilized HV375011 Human CD272/BTLA Recombinant Protein (C-His) at 2 μg/mL(100 μL/well) can bind MV480011 Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc), the EC 50 is 13.1 ng/mL.
Immobilized HV375021 Human BTLA Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind MV480011 Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc), the EC 50 is 251 ng/mL.
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