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Mouse Siglec-10 Recombinant Protein (C-Fc) (MV244011)

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사양:
  • 50ug
  • 100ug
  • 1mg
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  • 개요

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개요
카탈로그 번호MV244011
설명
Recombinant Mouse SIGLEC10 Protein, C-Fc (MV244011) expressed in Mammalian Cells, spanning Gln18-Lys543. Purity: >90% by SDS-PAGE.
Highlights
  • ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility.
  • ●Mammalian Expression — Proper folding and native glycosylation.
  • ●High Purity — >90% purity verified by SDS-PAGE.
발현 시스템Mammalian cells
등록번호Q80ZE3
단백질 길이Gln18-Lys543
응용 분야ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종Mus musculus (Mouse)
성질 Recombinant
내독소 수준 Please contact with the lab for this information.
순도 >90% as determined by SDS-PAGE.
예측 분자량 87.19 kDa
형태 Lyophilized
저장 완충액 Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

재구성 Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송 In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름SIGLEC10, SLG2, Sialic acid-binding Ig-like lectin 10, Siglec-10, Siglec-like protein 2
배경

Sialic acid-binding Ig-like lectin 10 is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion.

1. Duong, BH. et al. (2010) The Journal of experimental medicine 207, 173-87. PMID: 20038598
2. Hoffmann, A. et al. (2007) Nature immunology 8, 695-704. PMID: 17572677
3. Pfrengle, F. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 1724-31. PMID: 23836061
4. Chen, GY. et al. (2009) Science (New York, N.Y.) 323, 1722-5. PMID: 19264983
5. Jellusova, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 3618-27. PMID: 20200274
6. Ding, Y. et al. (2016) Nature immunology 17, 1167-75. PMID: 27548433
참고사항 For research use only
이미지
참고 문헌
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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