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| 카탈로그 번호 | MX990012 |
|---|---|
| 설명 |
Recombinant Mouse TFAM Protein, N-His (MX990012) expressed in E. coli, spanning Ser43-Ile200. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P40630 |
| 단백질 길이 | Ser43-Ile200 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Mus musculus (Mouse) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 20.73 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Mitochondrial transcription factor 1, MtTF1, TCF-6, TCF6, TCF6L2, TFAM, Transcription factor 6, Transcription factor 6-like 2, Transcription factor A, mitochondrial, mtTFA |
| 배경 | Transcription factor A, mitochondrial is a ~27 kDa protein. Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. 1. Larsson, NG. et al. (1998) Nature genetics 18, 231-6. PMID: 9500544 2. Kaufman, BA. et al. (2007) Molecular biology of the cell 18, 3225-36. PMID: 17581862 |
| 참고사항 | For research use only |
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