Anti-Human Integrin beta 2/CD18 Reference Antibody (LDP-01, RUO) (HY378023)

Name: Anti-Human Integrin beta 2/CD18 Reference Antibody (LDP-01, RUO)
Brand: abinScience
SKU: HY378023
Price: 176 USD
Availability: InStock

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100ug
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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HY378023

설명

Anti-CD18/ITGB2 (LDP-01) (HY378023) is a research-grade recombinant antibody targeting CD18. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

종 반응성

Human

응용 분야

ELISA, Bioactivity: FCM, Functional assay, Research in vivo

숙주 종

Human

클론성

Monoclonal

이소타입

IgG-nd

클론 ID

LDP-01

타겟

CD18, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, ITGB2, Integrin beta-2, MFI7

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

P05107

형태

Liquid

저장 완충액

0.01M PBS pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Integrin beta-2 (CD18/ITGB2) is a ~84 kDa protein. Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain.

1. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048

2. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 23775590

3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629

4. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055

5. Van der Vieren, M. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1984-90. PMID: 10438935

6. Van der Vieren, M. et al. (1995) Immunity 3, 683-90. PMID: 8777714

7. Grayson, MH. et al. (1998) The Journal of experimental medicine 188, 2187-91. PMID: 9841932

8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 15356110

9. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992

10. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980

참고사항

For research use only. Not suitable for clinical or therapeutic use.

이미지

SDS-PAGE

SDS-PAGE for Research Grade Anti-CD18/ITGB2 (LDP-01).

참고 문헌

데이터시트

Anti-Human Integrin beta 2/CD18 Reference Antibody (LDP-01, RUO).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human Integrin beta 2/CD18 Reference Antibody (LDP-01, RUO) (HY378023)

개요

이미지

참고 문헌

데이터시트

SDS

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