Anti-CXCR4 Reference Antibody (REGN7663, RUO) (HX206086)

Name: Anti-CXCR4 Reference Antibody (REGN7663, RUO)
Brand: abinScience
SKU: HX206086
Price: 370 USD
Availability: InStock

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사양:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HX206086

설명

Anti-CD184/CXCR4 Antibody (REGN7663) (HX206086) is a research-grade recombinant antibody targeting CD184.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

종 반응성

Human

응용 분야

ELISA, FACS, Functional assay

숙주 종

Human

클론성

Monoclonal

이소타입

IgG

클론 ID

REGN7663

타겟

C-X-C chemokine receptor type 4, CD184, CXC-R4, CXCR-4, CXCR4, FB22, Fusin, HM89, LAP-3, LCR1, LESTR, LPS-associated protein 3, Leukocyte-derived seven transmembrane domain receptor, Lipopolysaccharide-associated protein 3, NPYRL, SDF-1 receptor, Stromal cell-derived factor 1 receptor

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

P61073

형태

Liquid

저장 완충액

0.01M PBS pH 7.4

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

C-X-C chemokine receptor type 4 (CD184/CXCR4) is a ~39 kDa protein. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g.

1. Brelot, A. et al. (1999) Journal of virology 73, 2576-86. PMID: 10074102

2. Gupta, SK. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 2368-72. PMID: 10452968

3. Cheng, ZJ. et al. (2000) The Journal of biological chemistry 275, 2479-85. PMID: 10644702

4. Brelot, A. et al. (2000) The Journal of biological chemistry 275, 23736-44. PMID: 10825158

5. Veldkamp, CT. et al. (2008) Science signaling 1, ra4. PMID: 18799424

6. Busillo, JM. et al. (2010) The Journal of biological chemistry 285, 7805-17. PMID: 20048153

7. Malik, R. et al. (2010) Molecular biology of the cell 21, 2529-41. PMID: 20505072

8. Cao, Y. et al. (2015) Leukemia 29, 169-76. PMID: 24912431

9. Lear, T. et al. (2017) American journal of physiology. Cell physiology 313, C584-C592. PMID: 28978524

10. Bleul, CC. et al. (1996) Nature 382, 829-33. PMID: 8752280

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-CXCR4 Reference Antibody (REGN7663, RUO).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CXCR4 Reference Antibody (REGN7663, RUO) (HX206086)

개요

이미지

참고 문헌

데이터시트

SDS

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