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| 카탈로그 번호 | VK617106 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-HIV1 gp120/Glycoprotein 120 Antibody (mD1.22) (VK617106) is a research-grade recombinant antibody targeting CD4. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 종 반응성 | Human immunodeficiency virus type 1 (HIV-1) | ||||
| 응용 분야 | ELISA, Functional assay, Research in vivo | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | Fusion - [CD4 (LFA3, lymphocyte function associated antigen 3)]2 - IGHG1 Fc (Fragment constant) | ||||
| 클론 ID | mD1.22 | ||||
| 발현 시스템 | Mammalian cells | ||||
| 타겟 | T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, CD4 | ||||
| 내독소 수준 | < 10 EU/mg | ||||
| 순도 | >95% purity as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P01730 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | T-cell surface glycoprotein CD4 (gp120/Glycoprotein 120) is a ~51 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. | ||||
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
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