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| 카탈로그 번호 | HV427016 |
|---|---|
| 설명 |
Anti-Human CD246/ALK (CDX-0125-TEI) (HV427016) is a research-grade recombinant antibody targeting CD246. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | CDX-0125-TEI |
| 발현 시스템 | Mammalian cells |
| 타겟 | ALK, ALK tyrosine kinase receptor, CD246, Anaplastic lymphoma kinase |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q9UM73 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CDX-0125-TEI |
| 배경 | ALK tyrosine kinase receptor (CD246) is a ~176 kDa protein. Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis. Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response. In contrast, ALKAL1 is not a potent physiological ligand for ALK. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. 1. Souttou, B. et al. (2001) The Journal of biological chemistry 276, 9526-31. PMID: 11121404 2. Simonitsch, I. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 1416-8. PMID: 11387242 3. Gouzi, JY. et al. (2005) Journal of cell science 118, 5811-23. PMID: 16317043 4. Degoutin, J. et al. (2007) FEBS letters 581, 727-34. PMID: 17274988 5. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385 6. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012 7. Reshetnyak, AV. et al. (2021) Nature 600, 153-157. PMID: 34819673 8. Borenäs, M. et al. (2021) The EMBO journal 40, e105784. PMID: 33411331 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human CD246/ALK (CDX-0125-TEI)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
